ICRH Kenya

Use of nevirapine to reduce MTCT of HIV in a real-life situation

Team members:
Ann Quaghebeur; Fabian Mwanyumba; Patricia Claeys; Marleen Temmerman;


  • Coast Provincial General Hospital, Mombasa, Kenya


  • To assess the feasibility, acceptability and cost-effectiveness of te his easy-to-use regimen in a ‘real life’ situation.


  • The HIVNET012 regimen was implemented in a field setting
  • After informed consent, HIV-positive women were provided with nevirapine and instructions for use at the onset of labour
  • Follow-up visits were scheduled at 6 and 14 weeks
  • Perinatal transmission rate after the intervention was compared with transmission rate before



  • After implementing the nevirapine regimen, the perinatal HIV-1 transmission rate at 14 weeks was 18.1%, similar to the 21.7% before the intervention
  • These data call for further evaluation of the simple nevirapine regimen in field conditions, and underline the need for alternative strategies.
  • Results have been published in AIDS. 2003 May 23;17(8):1239-42 and AIDS. 2004 Sep 3;18(13):1854-6.