R Scott McClelland 1, Laura Sangare, Wisal M Hassan, Ludo Lavreys, Kishorchandra Mandaliya, James Kiarie, Jeckoniah Ndinya-Achola, Walter Jaoko, Jared M Baeten
Affiliation
- 1Department of Medicine, University of Washington, Seattle, WA 98104, USA. mcclell@u.washington.edu
PMID: 17262712
DOI: 10.1086/511278
Abstract
We conducted a prospective study among women in Mombasa, Kenya, to determine whether Trichomonas vaginalis infection was associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) infection. At monthly follow-up visits, laboratory screening for HIV-1 and genital tract infections was conducted. Among 1335 HIV-1-seronegative women monitored for a median of 566 days, there were 806 incident T. vaginalis infections (23.6/100 person-years), and 265 women seroconverted to HIV-1 (7.7/100 person-years). Trichomoniasis was associated with a 1.52-fold (95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women.
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